Objectives

Nanocarrier-based protein/peptide delivery systems will be developed for pulmonary, oral and blood brain barrier (BBB) crossing applications. These developments can have a huge impact on improving the quality of life of citizens in and outside Europe.

The objectivee of the NanoBioPharmaceutics project are:

• Design, synthesis and functionalization of novel nanocarriers and nanoparticle-based microcarriers for targeted delivery of P/P(protein/peptide) drugs via oral, pulmonary and blood brain barrier (BBB) crossing administration routes.
• Toxicological screening of the nanocarriers and investigation of the release profile of P/P drug under various environmental conditions and the assessment of the biocompatibility and biodegradability of the new formulations.
• Novel pulmonary P/P carriers with improved delivery features to overcome the administration difficulties and increase efficiency of protein delivery to the deep lung.
• Oral nanoparticulate P/P carrier systems capable of adhering to the gastrointestinal mucosa and also displaying protective and permeation enhancing properties.
• Development of an in vitro model for the assessment of nanocarriers permeability through the Blood Brain Barrier (BBB).